LymphedemaV1, Main, Exploration, bibRecord, 005005

Cleft lip and palate: synthesizing genetic and environmental influences

Identifieur interne : 005005 ( Main/Exploration ); précédent : 005004; suivant : 005006

Cleft lip and palate: synthesizing genetic and environmental influences

Auteurs : Michael J. Dixon [Royaume-Uni] ; Mary L. Marazita [États-Unis] ; Terri H. Beaty [États-Unis] ; Jeffrey C. Murray [États-Unis]

Source :

Nature reviews. Genetics [ 1471-0056 ] ; 2011.

RBID : PMC:3086810

Abstract

Clefts of the lip and/or palate (CLP) are common birth defects of complex etiology. CLP can occur in isolation or as part of a broad range of chromosomal, Mendelian, or teratogenic syndromes. Although there has been marked progress in identifying genetic and environmental triggers for syndromic CLP, the etiology of the more common non-syndromic (isolated) forms remains poorly characterized. Recently, using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP. These findings have advanced our understanding of developmental biology and created new opportunities for clinical translation research.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086810

DOI: 10.1038/nrg2933
PubMed: 21331089
PubMed Central: 3086810

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Clefts of the lip and/or palate (CLP) are common birth defects of complex etiology. CLP can occur in isolation or as part of a broad range of chromosomal, Mendelian, or teratogenic syndromes. Although there has been marked progress in identifying genetic and environmental triggers for syndromic CLP, the etiology of the more common non-syndromic (isolated) forms remains poorly characterized. Recently, using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP. These findings have advanced our understanding of developmental biology and created new opportunities for clinical translation research.</p>
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Cleft lip and palate: synthesizing genetic and environmental influences

Cleft lip and palate: synthesizing genetic and environmental influences

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